Florence kept its Jews behind a wall for nearly three hundred years, and this walk runs from the ground where that wall stood out to the synagogue the community built the moment it could. Do it in the morning, when Sant'Ambrogio's market is busy and the side streets are still cool.
Start in Piazza della Repubblica, the grand square punched through the demolished ghetto in the 1880s — read the self-congratulatory arch, then walk east the way the community moved. The Tempio Maggiore rises ahead, its green dome deliberately Moorish, deliberately tall: a people who had been hidden choosing, in 1882, to be seen. Go inside for the gilded arabesques, or read it from the street; either way the defiance is the point. The Museo Ebraico in the complex carries the harder history, down to the 1944 deportations.
Then Via dei Pilastri, where the kosher bakery and butcher still trade with their doors open, and into Sant'Ambrogio market — the one Florentines use — for a counter coffee. End in Piazza dei Ciompi under Vasari's reassembled loggia. The C2 picks up just west.